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Prevalence of antibiotic sensitivity pattern of uropathogens in patients of different age-groups from western region of Nepal

Authors: Singh Randhir K, Dewasy Bijoylakshmi, Mallick Ram L and Kafle Tara K

Int J Med Res Health Sci.1-7 | pdf PDF Full Text

ABSTRACT
UTI, the most common bacterial infection in urinary tract, is a serious health- problem that occurs in millions of
people at any age in each year. Its empirical treatment is difficult worldwide. Local susceptibility-pattern of
uropathogens is, therefore, important. To determine prevalence of UTI-associated uropathogens and their
antibacterial sensitivity-pattern. The midstream urine samples were collected from patients of different age-groups,
followed by examination with semi-quantitative culture method and determination of antibacterial sensitivitypatterns
using Kirby-Bauer disc diffusion technique. Data were analyzed in MS-Excel, 2007, and chi-square was
used to test the significance. Out of 4872 samples, 34 % showed significant growth of pathogens. The patients were
from newborn to 80-years-old. Majority of UTI (55.2 %) were from middle-aged patients with 20-49 years-old and
83.9 % organisms were isolated from females. The gram-negative aerobic rods accounted for 83.11 % prevalence
and that of gram-positive was 16.88 %. The infections caused by E. coli (44.33 %), Klebsiella spp. (28.23 %), S.
saprophyticus (8.32 %), and S. aureus (6.27 %) were prevalent in middle-aged females. These females were
markedly associated with pathogens (χ2=25.14, p<0.001). The drugs such as levofloxacin, ofloxacin, ciprofloxacin,
ceftriaxone and cefotaxime were five most sensitive antibiotics. Conclusion: Out of 4872 samples, 34 % showed
significant growth. Females were markedly associated with pathogens (χ2=25.14, p<0.001). The infections caused
by E. coli, Klebsiella spp., S. saprophyticus and S. aureus were predominant and drugs like levofloxacin, ofloxacin,
ciprofloxacin, ceftriaxone and cefotaxime the sensitive antibiotics.

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