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Parenteral Opioid Analgesics Utilization Pattern in Amir-al-Momenin Hospital, Zabol-IRAN

Authors: Hossein Vatanpour, Hamed Sufi, Nahidd-Emam-Jomeh, Atoosa Khorramnia, Tannaz Bovand and Saba Vatanpour

Int J Med Res Health Sci.112-119 | pdf PDF Full Text

ABSTRACT
Opioids are the most available medicines to get rid of any general severe pain and avoiding of any deleterious
sequential that can worsen patient outcomes. Rational prescription of opioid analgesics with respect to the
possibility of abuse is a big concern in the medical care costs. Zabol, where is located in eastern part of Iran and
has common border with Afghanistanhas the most opioid traffic in the region. In this study the rational prescription
of parenteral opioid in Amir-al-Momenin general hospital was investigated. A retrospective drug utilization review
was performed on 509 in-patients who received parenteral opioids including Morphine, Pethidin, Pentazocin,
Fentanyl, Alfentanil, Sufentanil and Methadone from March 21sttoSeptember 23rd, 2011. Multivariate conditional
regression modeling was used to determine independent predictors for daily parenteral opioid consumption. Total
daily parenteral opioid consumption was 38.63 DDDs/100bed-days for Morphine, Pethidine and Pentazocin and
84564.78 PFEQs/100bed-days for Fentanyl, Alfentanil and Sufentanil and 766 mg for Methadone. Pethidine was the
most frequently prescribed parenteral opioid. Most patients who were prescribed by the intramuscular routes,
ordered PRN. Daily parenteral opioid consumption was the highest in the emergency ward whereas it was
considered as the lowest in the intensive care unit[ICU]. According to our findings, total daily parenteral opioid
consumption was almost high in Amir-al-Momenin Hospital. Unlike to some relevant factors that can effect on the
consumption of analgesic opioids like gender, age, drug-drug interaction and etc, we found no rational prescription
and consumption in the mentioned hospital.
Keywords: Drug; Utilization; Opioid; ATC/DDD; Hospital; Zabol

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