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Isolation and identification of pharmacologically active compounds in fruit of Pyrus pashia

Authors: Subhash Chandra, Sarla Saklani and Rohit K. Agrawal

Int J Med Res Health Sci.30-34 | pdf PDF Full Text

The aim of this work is to investigate pharmacological active compounds analysis and their anti-inflammatory
activity of Pyrus pashia fruit. In this work some pharmacological active compounds were isolated by column
chromatographic techniques and identification of their structure by spectroscopic (NMR, IR, Mass, UV, etc.)
methods. Lupeol, β-Sitosterol and β-Sitosterol –ß-D glucoside compounds were isolated. These compounds firstly
were isolated from Pyrus pashia fruit. The anti-inflammatory activity of these compounds has been investigated with
in vivo study. In this study, it has been shown that Pyrus pashia isolated compounds showed potent antiinflammatory
activity. The active ingredient in the extract that reduces the inflammation is not known at present.
There is ongoing research to isolate and characterize the bioactive compound (s) responsible for the antiinflammatory
activity of Pyrus pashia.
Keywords: Pyrus pashia, Mahal, Lupeol and Anti-inflammatory activity.

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