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Investigating and comparing effects of atropine and physostigmine in peripheral pain examination due to formalin injection on rats

Authors: Mohammad Pourahmadi, Hossein Kargar Jahromi, Nazanin Shafeie and Saeid Mahmoudi Teimourabad

Int J Med Res Health Sci.650-657 | pdf PDF Full Text

There areseveral neurotransmittersat feel the pain and processing nervoussystem, and until now cholinergic system
has not been well studied in this field. The purpose of this research is investigating effects of atropine and
physostigmine on the response of formalin pain test. We divided 50 male wistar head rats into 5 groups , first group
( saline normal injection 5 μ ) , second group ( 1% formalin injection into 50 μ ) , third group ( physostigmine
injection 0/1 mg / kg ) , fourth group (atropine injection 2 mg / kg ) , fifth group ( atropine injection 2 mg / kg and
physostigmine 0/1 mg/kg ) , after formalin injection , the animals were placed inside mirror pain machine and it was
recorded pain response at the time ranges 0-5 and 15-45 . Results investigated with spss software and ANOVA and
Duncan’s test. Formalin injection causes pain response in both time ranges. Atropine injection alone had no effect
on pain response. Physostigmine effect alone, with a significant reduction (p< 0/05) in the number of foot motions in
both stage and duration causesof licking and biting in the 15-45 minutes stage . Atropine and physostigmine
injections in fifth group cause significant reduction in the number of foot motions and duration of licking and biting
in the time range of 15-45 minutes.Perhaps there is a close relationship between cholinergic system and peripheral
pain that can be taken through the action of muscarinic receptors.

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