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High prevalence of multiple drug resistance among pediatric Escherichia Coli infections

Authors: Chaudhary Vigi, Sharma Gaurav, Chaudhary Naveen and Raghuvanshi R. K.

Int J Med Res Health Sci.166-169 | pdf PDF Full Text

Antimicrobial resistance is a serious health menace. Infections caused by multiple drug resistant organisms are on
rise making community acquired infections a physicians’ nightmare. A survey was conducted to evaluate the
prevalence of multiple drug resistant urinary tract pathogens affecting children in Jaipur. Urine samples were
collected from children below five years of age. The urine samples were defined as positive culture when a single
bacterial species was grown with colony count of >10
5 CFU/mL. A total of 240 urine samples were collected out of
which only 67 were culture positive. It was found that 67% and 18% of infection was produced by E. coli and
Staphylococcal species respectively. Other bacteria which produced urinary tract infection included Klebsiella,
Citrobacter and Pseudomonas. The antimicrobial sensitivity pattern of E. coli isolates were tested against 10
commonly prescribed antimicrobial drugs for urinary tract infection as E. coli was the most predominant
uropathogen. About 66 percent isolates showed resistance to 3 or more drugs. 46 percent E. coli isolates were
resistant to 5 antibiotics tested. The highest resistance was shown to Augmentin (64%). Resistance shown by E. coli
to Norfloxacin and Cefuroxime was 60%. About 94% isolates were sensitive to Netilmycin. None of the drugs tested
was effective against all E. coli isolates. This type of surveys can act as guidelines for initiating empirical treatment
of community acquired urinary tract infections until culture reports are generated.

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