In the absence of confirmed causes for around 50% of recurrent pregnancy loss (RPL) cases this study was conducted in order to evaluate the relationship between PAEP gene single nucleotide polymorphism (SNP) rs760140467 C>T and recurrent pregnancy loss (RPL) in Palestinian women. A retrospective case-control study was carried out during the period (August 2015 to April 2016). A total of 200 females, 100 RPL patients and 100 control women without previous history of RPL were included in the study. PAEP (rs760140467 C>T) polymorphism was tested by PCR-RFLP. Statistically significant difference existed between RPL cases and controls in terms of the genotypic and allelic distribution of the tested polymorphism. PAEP “T/C” genotype and “T” allele were significantly higher in the RPL group. The study showed, for the first time, that the “C/T” genotype and the “T’ allele of the tested polymorphism are strongly associated with RPL in the investigated population. This finding may lead to improved therapeutic approaches for those RPL cases.
Keywords: PAEP gene, rs760140467 C>T , polymorphism, recurrent pregnancy loss