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Female Obesity and Clinical Outcomes of Assisted Reproductive Technologies (ART): an Updated Systematic Review and Meta-analysis

Authors: HeidarHeidariKhoei, Leila Dehdehi, MiladMoloudizargari, Zahra Baninameh, SedigheRezaie-Chamani, GeaOliveri Conti, ShokoofeAzarbahra and KolsoomMohammadmoradi

Int J Med Res Health Sci.157-170 | pdf PDF Full Text

Assisted Reproductive Technology (ART) has been developed to be used for reproductive-age women with primary
and secondary infertilities. Obesity is a worldwide epidemic for both women and men and a major global health
concern. The direct effect of Body Mass Index (BMI) increase on the outcomes of ART is still unclear. This study
aimed to carry out a systematic review of the available scientific evidence to assess the effects of obesity on the
clinical outcome of ART treatment. Numerous studies have shown failure in ART due to increased BMIs in infertile
women; however, the impact of increased BMI on clinical effectiveness of ART still remains inconclusive. Using
results from 44 studies (831616 subjects) we conducted an updated systematic review and meta-analysis to highlight
this subject (clinical pregnancy rate, miscarriage rate and live-birth rate). Compared to the women with BMIs of 25
kg/m
2 or less, women with BMI 25 kg/m2 have a lower chance of pregnancy [risk ratio 0.91, 95% CI: 0.89-0.94]
as well as lower live-birth rates [risk ratio 0.81, 95% CI: 0.70-0.94], and show increased miscarriage rates [risk
ratio 1.35, 95% CI: 1.28-1.46]. Our findings indicate that elevated BMI and obesity requires more recognition as a
potential contributor to negative pregnancy outcomes and reduced live-birth following ART. The results of our
meta-analysis suggest that weight loss should be considered in overweight and obese women before the initiation of
infertility treatment

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