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EX VIVO STUDY OF GARCINIA MANGOSTANA L. (MANGOSTEEN) PEEL EXTRACT AND XANTHONES AS ANTI-ADIPOGENESIS IN HEPG2 CELL MODEL

Authors: Lusiana Darsono, Meilinah Hidayat, Maesaroh Maesaroh, Nurul Fauziah, Wahyu Widowati

Int J Med Res Health Sci.2015;4(3):566-571 | pdf PDF Full Text

ABSTRACT

Background: Anti-adipogenesis is one of proposed mechanism for anti-obesity. Adipogenesis regulation of obesity is important, so identification of anti-adipogenic activity is a potential strategy to find anti-obesity agent. Aim: The aim of this study is to evaluate the anti-adipogenesis potential of Garcinia mangostana L. peel extract (GMPE) compared to xanthones in HepG2 cells line as model. Material and Methods: GMPE was performed based on maceration method using distilated ethanol 70% as the solvent. The level of triglyceride and cholesterol and the inhibitory activity of triglyceride (TG) and cholesterol (CHOL) in HepG2 cells were assayed and determined as the anti-adipogenesis parameter. Results: The most active subtance to lower the triglyceride level was showed by GMPE in every concentration followed by the garcinone-C, γ-mangostin, garcinone-D and α-mangostin respectivelly. The highest activity to decrease the cholesterol level was showed by GMPE and followed by γ-mangostin, α-mangostin, garcinone-c, garcinone-d respectively.  Conclusion: GMPE posses the anti-adipogenesis potential in inhibiting TG and CHOL synthesis was better than any other xanthone (α-mangostin, γ-mangostin, garcinone-C and garcinone-D).

Keywords: Obesity, Adipogenesis, Garcinia mangostana L., HepG2, Triglyceride, Cholesterol.

How to Cite this Article

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Pubmed Style:


Lusiana Darsono, Meilinah Hidayat, Maesaroh Maesaroh, Nurul Fauziah, Wahyu Widowati. EX VIVO STUDY OF GARCINIA MANGOSTANA L. (MANGOSTEEN) PEEL EXTRACT AND XANTHONES AS ANTI-ADIPOGENESIS IN HEPG2 CELL MODEL .Int J Med Res Health Sci. 2015;4(3):566-571.


Web Style:


Lusiana Darsono, Meilinah Hidayat, Maesaroh Maesaroh, Nurul Fauziah, Wahyu Widowati. EX VIVO STUDY OF GARCINIA MANGOSTANA L. (MANGOSTEEN) PEEL EXTRACT AND XANTHONES AS ANTI-ADIPOGENESIS IN HEPG2 CELL MODEL.


AMA (American Medical Association) Style:


Lusiana Darsono, Meilinah Hidayat, Maesaroh Maesaroh, Nurul Fauziah, Wahyu Widowati. EX VIVO STUDY OF GARCINIA MANGOSTANA L. (MANGOSTEEN) PEEL EXTRACT AND XANTHONES AS ANTI-ADIPOGENESIS IN HEPG2 CELL MODEL .Int J Med Res Health Sci. 2015;4(3):566-571.

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