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Evaluation of serum biochemical profile of breast cancer patients

Authors: Chauhan P., Yadav R, Kaushal V and Beniwal P.

Int J Med Res Health Sci.1-7 | pdf PDF Full Text

Breast cancer is the most common cancer worldwide. The incidence and mortality rate is increasing in developing
countries as compare to developed countries. The aim of this study was to evaluate the effect of different courses of
chemotherapy treatment on serum biochemical profile of breast cancer patients. In the present study, two hundred
breast cancer patients were selected to study variations in serum biochemical level of breast cancer patients. The
mean values of blood urea nitrogen, creatinine, uric acid, aspartate aminotransferase (SGOT), alanine
aminotransferase (SGPT) and alkaline phosphatase was found to be 32.58±19.7mg/dl, 1.05±0.59mg/dl,
8.6±1.3mg/dl, 27.3±4.02U/L, 27.9±10.24U/L and 111±24.04U/L before the start of chemotherapy courses. The
mean values of total and direct bilirubin, total serum protein, albumin, Fasting and postprandial glucose level was
0.30±1.3mg/dl, 0.13±0.11mg/dl, 8.11±0.5g/dl, 3.5±0.07g/dl, 96±25 mg/dl and 110±25mg/dl before the start of
chemotherapy treatment. The level of serum blood urea nitrogen, uric acid, alkaline phosphatase, bilirubin and
post-prandial glucose level was found to be more than normal reference range; while the level of creatinine,
aspartate aminotransferase (AST or SGOT), alanine aminotransferase (ALT or SGPT), total serum protein, albumin
and fasting blood glucose level was reported to be within normal reference range during the different courses of
chemotherapy. In conclusion, present results suggest serum biochemical parameters as an important diagnostic
tool in the disease monitoring and metastasis.
Keywords: Breast cancer, Biochemical profile, chemotherapy, prognostic significance

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