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Effect of urinary tract infection on the urinary metabolic characteristic as a risk factor in producing urolithiasis

Authors: Alireza Eskandarifar, Abdullah Sedaghat, Masoomeh Abedini, Faegh Youssefi and Asadollah Fatholahpour

Int J Med Res Health Sci.229-232 | pdf PDF Full Text

Urinary metabolic disorders are one of the most common causes of stone formation in children. The purpose of this
study was to evaluate the effect of urinary tract infections in the urinary metabolic characteristics as a risk factor in
the incidence of urolithiasis. This case-control study was conducted in 222 children with urolithiasis in the range of
6 months to 16 years old in Sanandaj, Kurdistan, Iran during 2012-14. Patients were divided into two groups based
on those with urinary tract infection and without urinary tract infection. Then, urine samples were collected from
both groups, and levels of calcium, oxalate, citrate, uric acid, creatinine, and cysteine were measured. The collected
information was analyzed using software SPSS (version 16). The ratio Average levels of calcium, magnesium,
oxalate, cysteine, uric acid to creatinine in urine showed no significant difference between two groups based on
statistical analysis. However, the amount of citrate to creatinine in children with urinary tract infection and
urolithiasis was clearly less P=0.01. The results of this study show that the urinary tract infection cannot change the
urinary metabolic characteristics, but it can be considered as a risk factor in kidney stone formation due to the
reduced amount of citrate in the urine.

Key words: Urolithiasis, Urinary tract Infection, Urinary metabolic characteristics

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