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Effect of Resistance Exercise Training Associated with Skeletal Muscle Hypertrophy on Serum Pro-Inflammatory Cytokines in STZ-induced Diabetes

Authors: Mahdieh Molanouri Shamsi, Mohsen Fallah and Mohammad Ghaderi

Int J Med Res Health Sci.229-234 | pdf PDF Full Text

Skeletal muscle atrophy is associated with type 1 diabetes. Effects of resistance exercise training associated with
skeletal muscle hypertrophy on serum inflammatory cytokines was exactly not clarified. Protein levels of
inflammatory cytokines IL-6, TNF-α, and interleukin-1beta (IL-1β) in serum of healthy and streptozotocin (STZ)-
induced diabetic rats subjected to resistance exercise training were assessed in this study. Rats were divided into the
control, training, control diabetic and diabetic training groups. Training groups performed the resistance training
consisted of climbing a 1 m ladder with increasing weight added to the tail. Proteins levels of IL-6, TNF-α and IL-1β
in serum were measured by the ELIZA method. The results of this study indicated that resistance training induced
skeletal muscle hypertrophy in diabetic samples (P<0.05). Also, Resistance training decrease IL-6 protein levels in
serum. Inflammatory cytokines could act as stress factors in diabetes. It seems that this kind of exercise training
individually could not change cytokines levels in serum.

Key words: Inflammatory cytokines, Resistance training, Type-1diabetes

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