Authors: Muninathan N, Ursula Sampson, Prashanth Talikoti, Uma Maheshwari, Archana, Kumar
Our recent studies have shown that naturally occurring dietary organo sulfure compounds such as di allyl sulfide and paclitaxel are capable of inhibiting polycyclic aromatic hydrocarbon (PAH) metabolism and subsequent PAH-DNA adduct formation in Wistar rats. In this study these plant phenols were tested for their effects against PAHs and 7,12 Di Methyl Benz (A) Anthracene -induced skin tumorigenesis in rats. Each compounds was evaluated as a possible anticarcinogen in an initiation and promotion and a complete skin tumorigenesis protocol. In the two-stage tumor protocol in Wistar rats using 7,12-dimethylbenz(a)anthracene as the initiating agent followed by twice weekly applications of acetone as tumor promoter each plant compounds afforded significant protection against skin tumorigenicity. The protective effects were verified both by prolongation of latency period and by subsequent tumor development. Our results suggest that these plants compounds have substantial though variable potential for modifying the risk of skin tumorigenicity induced by a wide variety of chemicals and of these combinations of Paclitaxel and Di allyl sulfide was shown to have maximal chemo protective effects.
Keywords: Paclitaxel, Di allyl sulfide, DMBA, Skin cancer.