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Detection of Porphyromonas gingivalis DNA in the synovial fluid of rheumatoid arthritis patients by real-time PCR

Authors: Reza Ghotaslou, Mohammadreza Nakhjovani, Javid Sadeghi, Hamed Ebrahimzadeh Leylabadlo, Behrouz Daghighazar and Solmaz Mirmahdavi

Int J Med Res Health Sci.661-665 | pdf PDF Full Text

Microbial infections are believed to play an important role in the initiation and perpetuation of rheumatoid
arthritis. This study aimed to investigate the relationship between the presence of Porphyromonas gingivalis DNA in
the synovial fluid and rheumatoid arthritis. The synovial fluid samples were collected from 22 patients with
rheumatoid arthritis and 20 patients with not suffering from rheumatism, overall 42 patients were investigated. The
presence of P. gingivalis DNA was evaluated by the real-time PCR method. There was a significant relationship
between rheumatoid arthritis and non-rheumatoid arthritis with the DNA number (Pv< 0.05). P. gingivalis DNA
were detected in 3 of 20 (13.6%) rheumatoid arthritis patients, but there was no significant relationship between P.
gingivalis DNA and rheumatoid arthritis (Pv> 0.05). DNA of periodontal pathogens can be found in the synovial
fluid of rheumatoid arthritis patients. It shows oral bacteria may play a role in the pathogenesis of rheumatoid
arthritis.

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