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Comparison of the effect of omega-3 fatty acids and perforan (Hypericumperforatum) on severity of premenstrual syndrome (PMS): a randomized trial

Authors: MasoomehKheirkhah, Roya Gholami, SimaYounesiGhare-shiran and Hanie Abbasinia

Int J Med Res Health Sci.333-340 | pdf PDF Full Text

Premenstrual syndrome (PMS) encompasses a wide variety of cyclic and recurrent physical, emotional, and behavioral symptoms that occur
before menstruation and has negative impact on activities of daily living, social activities, sexual functioning and quality of life. The aim of the
present study was to compare the effect of omega-3 fatty acid and perforan (Hypericum perforatum) on severity of premenstrual syndrome
(PMS). This study is a triple-blind clinical trial that was carried out across three groups with 150 students after considering inclusion and
exclusion criteria. The subjects of this study were randomly divided into three groups include omega-3 fatty acid group, perforan group and
control (placebo) group. Every subject in this study took drugs during three subsequent cycles so they took capsules daily in the first cycle for one
month and in the second and third cycles they took them from eight days before menstruation to two days after and recorded the severity of
premenstrual syndrome questionnaire. Statistical analyses were performed using SPSS version 17. The repeated measures ANOVA, chi-square
and Wilcoxon tests were used to compare mean differences in three groups. The data showed that there were no significant differences between 3
groups before the intervention but 1, 2 and 3 months after consumption of perforan and omega-3 capsules, the severity of PMS was significantly
lower than that in control group (p<0.001). perforan and omega-3 significantly reduce the severity of PMS

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