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Chromatographic determination of alpha beta momocharin and its effects with the combination of temozolamide and vinblastine in the treatment of glioma cancer In-Vivo

Authors: Gunasekar Manoharan and Mohammed Al Bratty

Int J Med Res Health Sci.191-197 | pdf PDF Full Text

Prior to the availability of chemotherapeutic agents, dietary measures, including traditional medicines derived from
plants, were the major forms of cancer treatment. One such plant is M.charantia (Family: Cucurbitaceae), whose
fruit is known as Karela or bitter gourd. M.charantia is believed to posse’s anti-carcinogenic properties and it can
modulate its effect via xenobiotic metabolism and oxidative stress. Different concentration (200μM – 800μM)of the
alpha and beta momorcharin a protein extracted from bitter gourd fruit, were treated (24 hrs incubation) separately
with six different cancer cell lines 1321N1, Gos-3, U87-MG, Sk Mel, Corl -23, Weri Rb-1 and normal L6 muscle cell
line. The results also show that combining either temozolomide (240 μM) or vinblastine (40 μg) with (800 μM)
alpha and beta momorcharin, result in significant decreases in cell viability for each cell line, these effects were
additive compared to the individual effect of temozolomide or vinblastine.

Keywords: Cancer cell lines, Momordicacharantia (MC)alpha, beta momorcharin (α, β),temozolomide (TMZ)
andvinblastine (VIB).

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