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Anxiolytic-like activity of ethanol extract of Ganoderma Lucidum (Reishi) in mice

Authors: Nasir Ali, Aslam Muhammad and Sial Ali Akbar

Int J Med Res Health Sci.57-60 | pdf PDF Full Text

Ganoderma lucidum is used for the treatment and prevention of many ailments including arthritis, hepatitis,
hypercholesterolemia, bronchitis, gastric cancer and hypertension. In this study we have evaluated the potential
anxiolytic-like activity of the mushroom in mice models of anxiety. Light/dark box and elevated plus maze test were
used to evaluate the anxiolytic-like activity of ethanol extract of fruiting bodies and cracked spores of Ganoderma
lucidum. The extract was given orally by gavage at the dose of 20 mg/kg, 75 mg/kg and 130 mg/kg body weight.
Diazepam (1 mg/kg i.p.) was used as the standard drug. The results reveal that Ganoderma lucidum demonstrated
significant increase in the time spent in light cubicle when compared with the control group in light/dark box test
and the results of elevated plus maze test reveal that Ganoderma lucidum, showed significant increase in the time
spent in open arms and number of open arm entries when compared with the control group. Overall evidences
propose that ethanol extract of Ganoderma lucidum has anxiolytic activity which is comparable to 1 mg/Kg
diazepam.

Key words: Ganoderma lucidum, Anxiety, Light/dark box test, Elevated plus maze test

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