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A Comparative Study on Different Doses of Pethidine and Ketamine for Prevention of Shivering During and After Spinal Anesthesia at Cesarean Section

Authors: Hasan Zabetian, Navid Kalani, Mohammad Sadegh Sanei, Mansour Deylami, Hossein Kargar Jahromi and Farzad Poorgholami

Int J Med Res Health Sci.303-307 | pdf PDF Full Text

Postoperative shivering is a common complication during anesthesia, which is usually accompanied with other
problems such as increased oxygen intake, increased intracranial pressure and several other complications. This
study attempted to compare different doses of pethidine and ketamine for prevention of shivering during and after
spinal anesthesia at cesarean section. This was a double-blind randomized clinical trial comprising a population of
45 pregnant women in three 15-subject groups receiving 0.3 and 0.15 mg of ketamine per kg body weight as well as
25 mg of pethidine. Admitted to Motahari Hospital in Jahrom (Iran), the subjects went through selective cesarean
section under spinal anesthesia. Data were analyzed through SPSS 16, t-test, Chi-square and Kruskal–Wallis. The
P-value was considered significant at lower than 0.05. As for ketamine 0.15, on patient (6.7%) experienced mild
shivering at 5, 10, 15 and 30 minutes. The intensity of shivering in recovery between ketamine 0.3, ketamine 0.15
and pethidine 25 mg was not significant at 5, 10, 15, 30 and 45 minutes (p-value> 0.05). Although a dose of 0.15
and 0.3 mg per kg led to shivering control, pethidine was still a better choice for shivering control.

Keywords: pethidine, ketamine, shivering

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