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A comparative study of Epstein-Barr virus (EBV) in malignant tumors and fibrocystic lesions of the breast

Authors: Zarichehr Vakili, Syed Alireza Moraveji, Tahereh Khamechian, Hasan Ehteram, Mahzad Eramiand Sepideh Abdi Soofi

Int J Med Res Health Sci.221-228 | pdf PDF Full Text

Breast cancer is the most common non-skin malignancy and the second leading cause of death due to cancer in women (after
lung cancer). Several factors involved in this disease have been studied. EBV has been proposed as a possible cause of breast
cancer in humans. Information related to the possible association of EBV with breast cancer is contradictory and inconclusive.
Therefore, we started to examine the role of this virus in breast cancer. The study was conducted on paraffin-embedded samples
of patients with breast cancer (case or experimental group) and fibrocystic lesions (control group) available in the archives of
pathology laboratory of Shahid Beheshti Hospital of Kashan related to 2012-2013. Samples DNA was extracted and infection
with EBV virus was analyzed using PCR method. SPSS-21 was used for data analysis. The frequencies were compared with Chisquare
test and the means with t-test. In this study, out of 40 patients with cancer, 14 patients (35%), and out of 40 patients with
fibrocystic lesion, 25 patients (62.5 percent) were positive regarding EBV virus (p=0.02). In the samples of cancer, no significant
differences were obtained between the two groups of positive and negative EBV in terms of average age (p=0.38), average
menarche age (p=0.16), average age of menopause (p=0.18), and the average age the first birth (p=0.97). In addition, no
statistically significant differences were observed between positive and negative groups in terms of tumor size. The results of this
study showed that EBV is significantly more in fibrocystic lesions than in breast cancer. Thus, no etiologic relationship was
found between EBV infection and Invasive Ductal Carcinoma (IDC) of Breast in this study, and more research is needed to
clarify the role of this virus in causing breast cancer.

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